Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.

Semax and its C-terminal fragment Pro-Gly-Pro increased transcription of BDNF, NGF and their cognate receptor genes following cerebral ischemia, supporting a neurotrophin-mediated neuroprotective mechanism.

Investigated as a preclinical (rat cerebral ischemia) in the field of neuroscience research. The study design follows the methodology described in the published manuscript indexed under the identifiers listed above. Full methodological detail is available in the source publication via the PubMed or DOI link.

Semax and its C-terminal fragment Pro-Gly-Pro increased transcription of BDNF, NGF and their cognate receptor genes following cerebral ischemia, supporting a neurotrophin-mediated neuroprotective mechanism.

Animal model of stroke; translational efficacy still requires controlled human trials.

• · PubMed: PMID 19633950 ↗
• · PubMed Central: PMC11498467 ↗
• · DOI: 10.1007/s10571-009-9432-0 ↗
• · PubMed search by title: pubmed.ncbi.nlm.nih.gov ↗
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