Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. · Brain Research
Semax up-regulated BDNF and TrkB expression in the rat hippocampus, providing a molecular substrate for its reported cognitive and neuroprotective effects in animal models.
Investigated as a preclinical (rat hippocampus) in the field of neuroscience research. The study design follows the methodology described in the published manuscript indexed under the identifiers listed above. Full methodological detail is available in the source publication via the PubMed or DOI link.
Semax up-regulated BDNF and TrkB expression in the rat hippocampus, providing a molecular substrate for its reported cognitive and neuroprotective effects in animal models.
Rodent model; effect sizes in humans are not characterised.
- · PubMed: PMID 16996037 ↗
- · DOI: 10.1016/j.brainres.2006.07.108 ↗
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