Effects of NAD+ supplementation with oral nicotinamide riboside on vascular health in older adults.

Oral nicotinamide riboside supplementation in older adults was associated with measurable changes in markers of vascular function, supporting investigation of NAD+ precursors as a strategy for age-related endothelial decline.

Investigated as a clinical trial (older adults) in the field of metabolic research. The study design follows the methodology described in the published manuscript indexed under the identifiers listed above. Full methodological detail is available in the source publication via the PubMed or DOI link.

Oral nicotinamide riboside supplementation in older adults was associated with measurable changes in markers of vascular function, supporting investigation of NAD+ precursors as a strategy for age-related endothelial decline.

Modest sample size; vascular surrogate endpoints rather than hard cardiovascular outcomes.

• · PubMed: PMID 40479886 ↗
• · PubMed Central: PMC13095416 ↗
• · DOI: 10.1016/j.jpet.2025.103607 ↗
• · PubMed search by title: pubmed.ncbi.nlm.nih.gov ↗
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