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NAD+ and sirtuins in aging and disease.

Mixed2014review (molecular biology of ageing)NAD+ →

Imai S, Guarente L. · Trends in Cell Biology

PubMed · PMID 24786309 DOI 10.1016/j.tcb.2014.04.002 PMC · PMC4112140 Search PubMed Google Scholar
Abstract / Summary

Foundational review describing how declining NAD+ availability with age impairs sirtuin-dependent regulation of metabolism, DNA repair and mitochondrial function, providing the mechanistic rationale for testing NAD+ precursors in age-related disease.

Methods

Investigated as a review (molecular biology of ageing) in the field of metabolic research. The study design follows the methodology described in the published manuscript indexed under the identifiers listed above. Full methodological detail is available in the source publication via the PubMed or DOI link.

Results

Foundational review describing how declining NAD+ availability with age impairs sirtuin-dependent regulation of metabolism, DNA repair and mitochondrial function, providing the mechanistic rationale for testing NAD+ precursors in age-related disease.

Limitations

Conceptual review; does not provide clinical outcome data.

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