UPTIDE
Pathway

GLP-1 Signalling

GLP-1 binds GLP-1R on pancreatic beta-cells to enhance glucose-dependent insulin release, while central GLP-1 signalling modulates satiety circuits.

Diagram

GLP-1ligandGLP-1Rreceptorβ-celleffectorInsulinoutcomeCNS satietyoutcome

Related compounds

Investigated in the context of this pathway

Semaglutide — Uptide research-grade vial
Human Clinical

Semaglutide

4113.58 g/mol

GLP-1 receptor agonist

MetabolicEndocrine
Retatrutide — Uptide research-grade vial
Human Clinical

Retatrutide

≈4731 g/mol (literature)

Triple-hormone-receptor agonist

MetabolicEndocrine
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