Pathway

GH / IGF-1 Axis

Hypothalamic GHRH stimulates pituitary somatotrophs to release growth hormone, which acts on hepatic and peripheral tissues to induce IGF-1, regulated by negative feedback from somatostatin.

Diagram

Related compounds

Investigated in the context of this pathway

Limited Human

CJC-1295 with DAC

3647.2 g/mol

Long-acting GHRH analog

Endocrine

Limited Human

CJC-1295 without DAC

3367.95 g/mol

Short-acting GHRH analog

Endocrine

Human Clinical

Sermorelin

3357.93 g/mol

Synthetic GHRH analog

Endocrine

Human Clinical

Tesamorelin

5135.79 g/mol

Synthetic GHRH analog

EndocrineMetabolic

Human Clinical

HGH Somatropin

22 124 Da (literature)

Recombinant human growth hormone

EndocrineMetabolic

Preclinical

Ipamorelin

711.86 g/mol

Pentapeptide growth hormone secretagogue

Endocrine